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| City | Defiance |
| State | Missouri (MO) |
| County | St. Charles |
| Country | United States of America |
| Timezone | Central Time (America/Chicago) |
| Latitude | 38.632275 |
| Longitude | -90.778464 |
| Population | 63 |
| Density | 30.5 /km² |
| Incorporated | N/A |
| ZIP Code(s) | 63341 |
| Area Code | 314 |
| County Seat | St. Charles |
| School District | Francis Howell R-III School District |
Defiance is a locality in St. Charles County, Missouri, United States. It is a small community with a population of 63. The population density is 30.5 people per km². Defiance is located at 38.6323°N, 90.7785°W. It observes the Central Time (America/Chicago) timezone. ZIP code: 63341.
Defiance rests in a quiet fold of land where the Missouri River, a broad, brown artery, shapes the horizon with its patient flow. It lies 7.1 miles west-north-west of Wildwood, MO (from Wildwood, MO: bearing 299°T), and is situated 9.8 miles south-south-west of Dardenne Prairie. Rolling hills, cloaked in a patchwork of dense woodland and fertile farmland, rise gently from the riverbanks, their slopes catching the sun in shifting patterns of light and shadow. The air here, particularly in the late afternoon, carries a subtle coolness, a blend of damp earth and the distant murmur of unseen water, a scent that speaks of the land's enduring agricultural character. Oak and hickory trees, their branches reaching like gnarled fingers, dominate the higher ground, while the lower fields, meticulously tended, promise a good harvest, their greens and golds a testament to the careful work of generations. The history of Defiance is deeply entwined with the westward expansion and the enduring spirit of those who sought a life along this mighty waterway. Early settlers, drawn by the rich soil and the river's promise of transportation, established a foothold here, carving out a livelihood from the untamed landscape. Today, the local economy still whispers of those agrarian roots, with vineyards and orchards dotting the surrounding countryside, their produce often finding its way to local markets and wineries that draw visitors seeking a taste of authentic Missouri. The nearby Katy Trail State Park, a ribbon of crushed limestone following the path of an old railway, further connects Defiance to its past, offering a popular route for cyclists and hikers who appreciate the scenic beauty and the palpable sense of history that permeates the very soil.
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This page provides an embedded street and satellite map of Defiance, Missouri — switch between views using the small square in the bottom left-hand corner of the map. Coordinates: 38.632275, -90.778464. Live weather conditions are sourced directly from the National Weather Service, with current observations and a 7-day forecast also powered by Open-Meteo. Real-time local news and world news feeds keep the page current, while a Wikipedia summary or an editorially written description provides background on Defiance and St. Charles County.
Detailed location data for Defiance includes the ZIP code (63341), telephone area code (314), county seat of St. Charles County (St. Charles), and school district assignment (Francis Howell R-III School District). These are among the most commonly searched location details for any US city or town.
Location data is drawn from the USGS Geographic Names Information System (GNIS) and cross-verified against 2020 US Census records by coordinate proximity — ensuring the correct Defiance is identified even where the name is shared across multiple counties or states. Population figures are sourced from the 2020 US Census.
| Page generated | July 2026 |
| Location data | SimpleMaps US Cities Database; coordinates matched to USGS GNIS definitive data |
| Wikipedia validation | Article content matched to USGS GNIS coordinates via Wikipedia geosearch API. Location verified by proximity — not name matching alone. |